The three questions worth asking of any Mac cleaner
What does it show you before it removes anything? The answer should be “every file, with its size and where it came from”. If a button says “clean” and a number goes down, you have not been shown anything.
Where do the files go? The Trash, so a mistake costs you a restore rather than a backup. DiskDuo has no immediate-delete default and no shortcut for it.
What leaves the machine? Read the privacy policy before you install. DiskDuo collects nothing: no analytics, no crash reporting, and no file names anywhere.